Head of Data Science
Company: Ascidian Therapeutics, Inc.
Location: Boston
Posted on: May 19, 2024
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Job Description:
Who are we looking for?
We are seeking a talented and highly motivated leader with a deep
understanding of computational biology and its potential to
transform drug discovery. You will have deep technical savvy, a
strategic mindset, and clear, forwarding-thinking leadership in
AI/ML, computational biology and molecular biology, with a proven
track record of leveraging computational tools to drive innovation
in biotechnology, particularly in the realm of molecular biology,
genome/transcriptome-wide analysis, single cell analytics,
molecular design and structure, next generation sequencing, to
predict RNA structure, regulation, and splicing. This role will be
pivotal in shaping the company's scientific strategy and ensuring
its successful execution.
Your contribution to Ascidian
Collaborate with the executive leadership team to define and refine
the scientific strategy, ensuring its alignment with business
goals.
Responsible for experimental design, analysis, and interpretation
of large data sets including bulk RNA-seq,
single-cell/single-nucleus RNA seq, single-cell ATAC seq,
single-cell barcoding strategies, spatial transcriptomic data, and
imaging analysis.
Develop and deploy barcoding strategies to enable the collection of
robust and reproducible data from highly multiplexed in-vivo
experiments.
Develop and deploy both classical data science and cutting-edge ML
methods to analyze data from diverse 'omic modalities, including
transcriptomic and imaging data, addressing challenges such as
distribution shift, experimental artifacts, data sparsity, and
more.
Work with lab colleagues to design experiments that generate
datasets that are fit for purpose for machine learning, including
ones generated explicitly for training ML models.
Mentor and guide the computational team, fostering a culture of
innovation and excellence.
Establish partnerships with academic institutions and other third
parties to stay abreast of emerging technologies and models.
Foster a collaborative environment, working closely with R&D
leaders and program heads to ensure seamless integration of
computational tools with experimental workflows.
What you need to succeed
PhD in computational biology, data sciences, bioinformatics,
mathematics, engineering or a related field.
8+ years in the biotech or related industry with a focus on being
technically excellent, strategic and innovative.
Demonstrated leadership in computational biology or related
fields.
Proven track record of publications in high-impact journals or
significant industry contributions.
Strong familiarity with RNA biology, RNA processing,
ribonucleoprotein structures and their interactions.
Experience in guiding teams in the deployment of machine learning
platforms and bioinformatics tools.
Experience with protein co-evolution analysis and NGS tools.
Exceptional communication skills, with the ability to convey
complex ideas to diverse audiences.
Familiarity with a startup or fast-growing biotech environment,
with established network within the biotech and computational
biology communities, is preferred.
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Keywords: Ascidian Therapeutics, Inc., Haverhill , Head of Data Science, Other , Boston, Massachusetts
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